Key points:
- Changes to how our genes are turned on and off are critical to health but are difficult to study.
- A new technology called FIRE pairs machine learning with advanced DNA sequencing to find regions that are crucial for gene regulation.
- FIRE provides an unprecedented look at previously mysterious parts of our DNA and reveals a new dimension of biological variability that isn’t determined by genetics.
IMPACT: The tool could help pinpoint the DNA changes behind hereditary diseases—a crucial step toward genetic medicines.
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